ENGINEERING A VERSATILE AND RETRIEVABLE CELL MACROENCAPSULATION DEVICE FOR THE DELIVERY OF THERAPEUTIC PROTEINS

Engineering a versatile and retrievable cell macroencapsulation device for the delivery of therapeutic proteins

Summary: Encapsulated cell therapy holds a great potential to deliver sustained levels of highly potent therapeutic proteins to patients and improve chronic disease management.A versatile encapsulation device that is biocompatible, scalable, and easy to administer, retrieve, or replace has yet to be validated for clinical applications.Here, we repo

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In Defence of Environmental Anthropocentrism

The critique of anthropocentrism has accompanied environmental thinking since its inception.However, we lack a deeper analysis of anthropocentrism and its forms.The authors of this study concentrate on analysing selected forms of anthropocentrism that were prominent in different periods of the history of European culture.They offer a basic Glue Sti

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A generalized dual-domain generative framework with hierarchical consistency for medical image reconstruction and synthesis

Abstract Medical image reconstruction and synthesis are critical for imaging quality, disease diagnosis and treatment.Most of the existing generative models ignore the fact that medical imaging usually occurs in the acquisition domain, which is different from, but associated with, the image domain.Such methods exploit either single-domain or dual-d

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A novel nanohydroxyapatite/polyamide-66 cage for reducing the subsidence rate after single-level anterior cervical discectomy and fusion: a comparative study of 7-year follow-up

Abstract Background A novel nanohydroxyapatite/polyamide-66 cage (n-HA/PA66 cage) with a horseshoe Pillow shape was designed to lower the subsidence rate of the traditional hollow cylindrical n-HA/PA66 cage.However, no studies have compared the incidence of subsidence in the two cages.The purpose of this study was to compare the long-term clinical

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